AAV Gene Therapy
Vector Optimization
(Optimized AAV-engineering System)
ICM develops its gene therapies based on AAV gene delivery platform by optimizing therapeutic gene expression cassettes and capsid serotype. ICM's skills expedite efficient development of multiple gene therapy pipelines.
AAV-ITR
- Sequence & Length
Promoter
- Ubiquitous
- Targeted
- Strength
- Inducible
Intron & Spacers
- Expression Efficiency
- Backbone Architecture
Therapeutic Gene
- Disease-specific Target
Gene Modification - Tissue-specific Codon
Optimization
Termination
- Transcription Stop
Validation - Poly-A Tailing
Efficiency
AAV-ITR
- Sequence & Length
AAV-ITR
- Sequence & Length
Promoter
- Ubiquitous
- Targeted
- Strength
- Inducible
Intron & Spacers
- Expression Efficiency
- Backbone Architecture
Therapeutic Gene
- Disease-specific Target
Gene Modification - Tissue-specific Codon
Optimization
Termination
- Transcription Stop
Validation - Poly-A Tailing
Efficiency
AAV-ITR
- Sequence & Length